Pope Francis has for the first time named a woman to the number two position in the governorship of Vatican City, making her the highest-ranking woman in the world's smallest state, Reuters reported.

The appointment on Thursday of Sister Raffaella Petrini, a 52-year-old Italian nun, is the latest in which the 84-year-old pope has placed a woman in a leadership role.

Petrini's new position of secretary general of the Governatorate of the State of Vatican City is comparable to being deputy governor of a state or deputy mayor of a city. The Governatorate, based in a large palace in the middle of Vatican City, oversees more than 2,000 employees.

The appointment of Petrini marks the latest attempt by the pope to keep promises to improve gender balance made years ago.

A number of other women already hold number two posts in Vatican departments, but they deal with religious and social issues and have much smaller staff levels.

In August the pope named Italian nun Sister Alessandra Smerilli to the interim position of secretary of the Vatican's development office, which deals with justice and peace issues.

He has also appointed six women to senior roles in the council that oversees Vatican finances and women to the posts of deputy foreign minister, director of the Vatican Museums and deputy head of the Vatican Press Office.

Francis has said he sees no reason why a woman should not hold a top post apart from those that for doctrinal reasons are open only to ordained priests.